Wales international Kelsey Jones scored a hat-trick for Gloucester-Hartpury before being shown a red card towards the end of the game.
The 42-cap hooker put the Cherry and Whites into the lead against Saracens after a gruelling maul eventually found its way to the try line, and got her second shortly after Poppy Cleall was sin-binned for collapsing a maul.
She secured the hat-trick try by cutting an excellent line to bundle over the whitewash, but moments later was given her marching orders for a head-on-head tackle with 18 minutes to go.
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Despite Jones' sending off, it was her try-scoring exploits that helped propel Gloucester-Hartpury to victory, with an exceptional Emma Sing score putting the 'cherry' on icing on the cake of in a 24-15 scoreline.
The result leaves Gloucester-Hartpury second in the Allianz Premiership table, one point adrift of Saracens.
Wales Women get their Six Nations campaign underway on March 23 against Scotland at the Cardiff Arms Park. Jones will be hoping to continue her try-scoring form on international duty.